Melissa McCarthy isn't the only woman carving out her own slice of hilarity. Here are other women taking on the world of comedy their way.
REBEL WILSON, 28
This Aussie powerhouse's bit part in Bridesmaids (2011) led to more comedy projects in 2012, such as Bachelorette and What To Expect When You're Expecting.
However, it was through the 2012 sleeper hit Pitch Perfect where Wilson found her place in Hollywood.
Never one to be shy about her weight, the outspoken actress once proclaimed that she'll continue to make fat jokes.
Her talent isn't limited to just being an actress. She wrote and hosted the 2013 MTV Movie Awards and created acclaimed comedy series Super Fun Night.
Currently filming Night At the Museum: Secret Of The Tomb, Wilson will again sing and rap in the upcoming Pitch Perfect 2, where she reprises her Fat Amy character.
JILLIAN BELL, 30
Like McCarthy, this up-and-coming comedienne is a "graduate" of The Groundlings.
Bell turned heads with her snarky retorts in 22 Jump Street, where she played the creepy roommate of Jonah Hill's love interest in the hit comedy.
This Las Vegas blonde started getting recognition through the US comedy Workaholics, and more recently through Idiotsitter, the webseries she co-created with Charlotte Newhouse that has been picked up as a series by Comedy Central.
Bell's next big-screen project is Paul Thomas Anderson's crime mystery Inherent Vice, which also stars Reese Witherspoon and Joaquin Phoenix.
LENA DUNHAM, 28
Last year was nothing short of remarkable for this New Yorker.
The genius creator/writer/actor/director/producer behind the award-winning series Girls faced comedy heavyweights such as Julia Louis-Dreyfus, Tiny Fey and Amy Poehler for the 2013 Golden Globes award for Best Actress in a Musical/Comedy TV series.
Dunham took home the gold. That says a lot for the young lady who was unheard of before Girls - an unflinching comedy about the experiences of a group of girls in their early 20s - made its debut on HBO in April 2012.
Dunham is known for being a champion of "ordinary, imperfect girls", and one who challenges Hollywood's traditional idea of the female body.
While her success is from her work for the small screen, Dunham, who shot an indie called Tiny Furniture in 2010, isn't limiting herself to TV.
She recently starred in independent dramedy Happy Christmas by director Joe Swanberg (Drinking Buddies), sharing the screen with Anna Kendrick.