5 talking points
1 Clash of the top two
City have taken maximum points from their opening six games, but this is arguably their toughest test.
Tottenham are unbeaten and have won three in a row since a home draw with Liverpool last month. However, they are yet to face any of last season's top six.
2 Aguero can make up for injured de Bruyne
Spurs have been a happy hunting ground for Sergio Aguero in recent years. The Argentinian has hit 10 goals in nine league appearances against Mauricio Pochettino's men, including four in a 4-1 win for City two years ago.
3 Janssen feeling heat from Son
Despite his impressive work-rate and link-up play, Vincent Janssen has scored only once in nine appearances. Pochettino has a decision to make up front, particularly with Son Heung Min (pictured) scoring five in five games.
4 Possession versus pressing
Celtic showed that Pep Guardiola's side can be rattled by a team prepared to hassle them high up the pitch. City's defenders will be tested by a Spurs side determined to pressure even their opponents' goalkeeper, let alone the back four.
5 Pochettino with a point to prove
Pochettino is eager to establish himself as one of Europe's top young coaches and inflicting a first defeat on Guardiola in England would only add to his burgeoning reputation.
Guardiola has won five of their nine match-ups overall. - PA Sport.