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South African variant can ‘break through’ Pfizer vaccine: Study

JERUSALEMThe coronavirus variant discovered in South Africa can "break through" Pfizer-BioNTech's Covid-19 vaccine to some extent, a real-world data study in Israel found, though its prevalence in the country is low and the research has not been peer reviewed.

The study compared almost 400 people who had tested positive for Covid-19, 14 days or more after they received one or two doses of the vaccine, against the same number of unvaccinated patients with the disease. It matched age and gender, among other characteristics.

The South African variant, B1351, was found to make up about 1 per cent of all the cases across all the people studied, according to the study by Tel Aviv University and Israel's largest healthcare provider Clalit.

But among patients who had received two doses of the vaccine, the variant's prevalence rate was eight times higher than those unvaccinated - 5.4 per cent versus 0.7 per cent.

This suggests the vaccine is less effective against the South African variant, compared to the original coronavirus and a variant first identified in Britain that has come to comprise nearly all Covid-19 cases in Israel, the researchers said.

"We found a disproportionately higher rate of the South African variant among people vaccinated with a second dose, compared to the unvaccinated group. This means that the South African variant is able, to some extent, to break through the vaccine's protection," said Tel Aviv University's Dr Adi Stern.

The researchers cautioned, though, that the study had only a small sample size of people infected with the South African variant because of its rarity in Israel. - REUTERS

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