Van Persie is United's main man in attack. His tally of 10 goals from 14 league games this season highlights his importance to the Red Devils.
His goal last Sunday got them back into the game against Fulham when they were struggling for an opening.
Tomorrow, he will be up against Koscielny who has matured into a top quality centre half and who has been solid at the back alongside Per Mertesacker at the heart of Arsenal's defence.
The creative geniuses of both sides could decide the outcome, which may come down to one big chance.
Oezil's form has dipped in recent weeks following a scintillating start to his Arsenal career and boss Arsene Wenger will be hoping his masterful artistry with the ball will come to fruition in the big clash.
Mata, on the other hand, is still settling in at United but has the quality to open up any defence and his drifting in from the wings may cause problems.
The Arsenal frontman has come into his own this season and seems to revel when playing at the Emirates, scoring the vast majority of his Gunners goals on home turf.
Vidic, despite his impending departure, will still put his heart into every match and will relish the opportunity of a physical battle against the Frenchman. If he can limit Giroud's involvement, Arsenal may struggle to build attacks.
ROBIN VAN PERSIE
Despite their differing fortunes this season, tomorrow morning's (Singapore time) clash between Arsenal and Manchester United remains a standout fixture on the Premier League calendar.
PA Sport looks at the battles that could decide the game's outcome at the Emirates Stadium.